Idiopathic Male Infertility
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P-132: Analysis of Genetic Variation of Interleukin 1-α in Idiopathic Male Infertility
Background Despite enormous progress in the understanding of human reproductive physiology, the underlying cause of male infertility remains undefined in about 50.0% of cases, which are referred to as idiopathic infertility and already affects about 5.0-7.0% of the general male population. Interlukin- 1 is a regulator that plays an important role in maintaining a safe environment for testes and...
متن کاملP-120: Evaluation of OGG1 Ser326Cys Polymorphism in Idiopathic Male Infertility
Background Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In more than half of infertile men, the cause of their infertility is unknown (idiopathic) and could be congenital or acquired. OGG1 is a bifunctional glycosylaseii, in that it has both AP lyase and DNA glycosylase activity and one of its functions is to excise and remove 8-oxo-dGuo from DNA. Amon...
متن کاملO-5: The Influence of Genetic Polymorphism On Idiopathic Male Infertility
Background: Infertility is a multifactorial disorder affecting one in ten couples, and in 50% of infertile couples, the male factor due to deteriorated semen quality is a major cause. In about 30% of infertile men seeking help for their problem, the etiology and pathogenesis are not yet known and their condition is considered idiopathic. Through animal studies conducted recently, hundreds of ge...
متن کاملEmpiric medical therapy with hormonal agents for idiopathic male infertility
INTRODUCTION Infertility affects approximately 15% of all couples, and male factor contribute to up to 50% of cases. Unfortunately, the cause of male infertility is unknown in about 30% of these cases. Infertility of unknown origin is classified as idiopathic male infertility when abnormal semen parameters are present. Despite not having a definable cause, these men may respond to treatment. Th...
متن کاملIL-1ɑ C376A Transversion Variant and Risk of Idiopathic Male Infertility in Iranian Men: A Genetic Association Study
Objective IL-1α produces by sertoli cells and considered as a growth factor for spermatogonia. In this study we investigated the association of C376A polymorphism in IL-1α gene with male infertility in men referring to Kashan IVF center which followed by an in silico approach. MaterialsAndMethods In a case-control study, 2 ml blood was collected from 230 fertile and 230 infertile men. After DNA...
متن کاملAssociation of MTHFR, NFKB1, NFKBIA, DAZL and CYP1A1 gene polymorphisms with risk of idiopathic male infertility in a Han Chinese population
In this study, we investigated the association between six genetic polymorphisms (MTHFR C677T and A1298C, NFKB1 -94ins/del ATTG, NFKBIA 3’UTR A>G, DAZL A386G (T54A) and CYP1A1 T3801C) and the risk of idiopathic male infertility in a Chinese population. A case-control study comprising 1,759 idiopathic male infertile patients of Han Chinese ethnicity and 1,826 healthy fertile control individuals ...
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